The activation of CB1 and CB2 inhibits the development of intracellular cAMP, as a result bringing about a huge reduction in the excitatory outcome within the neurons [88,89]. On top of that, the activation of CB2 can more avert the mast mobile degranulation and the release of pro-inflammatory mediators, making the reduction in pain feeling even mo
The activation of CB1 and CB2 inhibits the formation of intracellular cAMP, consequently resulting in a tremendous reduction from the excitatory impact within the neurons [88,89]. On top of that, the activation of CB2 can even more prevent the mast mobile degranulation and the discharge of professional-inflammatory mediators, earning the reduction
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